Τα δισκία Wegovy είναι ένα καθημερινό στοματικό φάρμακο που περιέχει σεμαγλουτίδη, έναν αγωνιστή υποδοχέα GLP-1 που αναπτύχθηκε από τη Novo Nordisk (το ίδιο συστατικό που βρίσκεται στα στυλό ένεσης Ozempic και Wegovy). Το φάρμακο ενδείκνυται για ενήλικες με παχυσαρκία ή υπέρβαρο συνοδευόμενο από υγειονομικές επιπλοκές σχετιζόμενες με το βάρος, ενώ το Wegovy έχει επίσης εγκριθεί για τη μείωση του καρδιαγγειακού κινδύνου σε ασθενείς με εγκατεστημένη καρδιακή νόσο.

Η σεμαγλουτίδη λειτουργεί ως αγωνιστής υποδοχέα GLP-1, προάγοντας το αίσθημα κορεσμού και μειώνοντας την όρεξη για να υποστηρίξει τη βιώσιμη διαχείριση βάρους όταν συνδυάζεται με τροποποίηση της διατροφής και σωματική δραστηριότητα. Η θεραπεία απαιτεί ιατρική επίβλεψη και τήρηση ενός δομημένου πρωτοκόλλου αύξησης δόσης.

The main ingredient in Wegovy is semaglutide. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. This means it mimics the action of natural hormones that regulate appetite and food intake in the body. GLP-1 receptor agonists work by reducing hunger and increasing feelings of fullness, leading to decreased food intake and, consequently, weight loss. Semaglutide is administered via injection and is designed to be used alongside a reduced-calorie diet and increased physical activity for the management of obesity or overweight in adults with certain weight-related medical conditions.

Wegovy® tablets (oral semaglutide) may cause side effects as your body adjusts to the medication. Most are gastrointestinal and tend to occur during dose increases.
Common Side Effects
Nausea and Vomiting: Often manageable by eating smaller meals and avoiding fatty foods Wegovy Official Site.
Digestive Issues: Diarrhea, constipation, stomach pain, and bloating FDA Label.
General Malaise: Fatigue, dizziness, and headache Mayo Clinic.
Reflux: Heartburn or frequent belching.
Serious Side Effects (Seek Medical Attention)
Thyroid Tumors: A Boxed Warning exists for thyroid C-cell tumors; report any neck lumps or hoarseness immediately.
Pancreatitis: Severe abdominal pain that radiates to the back.
Gallbladder Problems: Upper stomach pain, fever, or yellowing of the skin (jaundice).
Kidney Injury: Often caused by dehydration from severe vomiting or diarrhea.
Hypoglycemia: Low blood sugar, especially if used with other diabetes medications.
Vision Changes: Specifically for patients with diabetic retinopathy.
Depression: Any sudden changes in mood or suicidal thoughts.

Wegovy comes with several warnings that users should be aware of. Firstly, it has been associated with an increased risk of pancreatitis, so patients experiencing severe abdominal pain should seek medical attention. Additionally, there's a potential risk of thyroid tumors, particularly in those with a history of thyroid cancer or a genetic predisposition. Patients should also be cautious about hypoglycemia, as Wegovy may lower blood sugar levels. Kidney function should be monitored regularly, especially in individuals with pre-existing kidney disease. Pregnant or breastfeeding women should consult healthcare providers before using Wegovy due to its unknown effects in these populations.